Samburu National Reserve is situated at the southeastern corner of Samburu District in the Rift Valley Province of Kenya. It is bordered to the south by Ewaso Nyiro River, which separates it from the Buffalo Springs National Reserve.
The reserve covers an area of 165 Km² and is located around 345Km from Nairobi.
The Reserve lies within ecological zone V- which is classified as arid and semi- arid with moisture index of 42 to 57, which indicate that evapo-transpiration is greater than available moisture. The days are extremely hot while the nights are cool. The annual mean temperatures range between 18ºC and 30ºC, while the mean annual rainfall is 354mm with peaks in November and April. The dry season starts in late May, and goes up to early October during when large concentration of wildlife is found in the reserve due to availability of lush vegetation along the Ewaso Nyiro River, the main source of water to the Reserve and the nearby communities.